Abstract

FORMULATION AND EVALUATION OF ETHYL CELLULOSE BASED CONTROLLED RELEASE METOPROLOL SUCCINATE MUPS IN TABLET FOR HYPERTENSION DISORDER

K. Sakthi* and Sathyaraj A. M. Pharm., (Ph. D)

ABSTRACT

Formulation and evaluation of Ethyl cellulose based controlled Release Metoprolol Succinate MUPS in Tablet for Hypertension disorder is important in ensuring patient safety and efficacy of the medication. Metoprolol succinate is a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties. It is used to treat Nocturnal high blood pressure causing heart attack. The main advantage of this formulation is allows patients who have difficulty to taken a multiple doses of Drug for once a day and repeated dose administration it causes fluctuation of drug concentration in plasma. Metoprolol succinate controlled release MUPS in tablet was formulated it will provide the predetermined rate of drug delivery for prolong period of time period of 10 Hrs at dose of 200mg per day. It involves the use of different excipients, which enhance the drug's characteristics and ensure optimal drug delivery. The excipients used in Metoprolol succinate MUPS in Tablet may include Diluent,Polymers, Glidant, Plasticizers and Lubricants. Polymers used to provide the controlled drug release for 10 hrs. Glidant, Plasticizers and lubricants are used to improve flow property and Diluent used to increase the weight of the Tablet. The evaluation of Ethyl cellulose based controlled Release Metoprolol Succinate MUPS in Tablet involves various tests, such as Drug content, dissolution, stability testing. Dissolution profile testing assesses the controlled rate of drug release from the tablet, which is important for drug efficacy. Stability testing ensures that the medication maintains its potency and quality over time, even under Accelerated stability conditions. In Conclusion the coated controlled release MUPS in tablets of Metoprolol succinate was designed drug release at predetermined rate and maintain the drug release at constant level. The intention was to administer the formulation at around 10.00 pm so that after a specified time the drug is rapidly available in the early morning to treat nocturnal Hypertension. Thus the above formulations is worth evaluating for chronotherapeutic treatment of nocturnal Hypertension.

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