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A. Anil Kumar*, T.E. Gopala Krishna Murthy, A. Prameela Rani


Innovations in the area of drug delivery are taking place at a much faster pace. As compared with last two decades, during the last decade many controlled drug delivery systems for oral administration have been developed by using many techniques. Even though these techniques are having lot of limitations and less applicable to weakly acidic or basic drugs which are exhibiting pH dependent solubility, Due to the pH-dependent solubility of ionizable drugs, oral tablets containing ionizable drugs are particularly prone to these release rate fluctuations. For such drugs Intra and Inter subject variability of entire GIT pH, patient related diseased conditions and the fast and fed conditions which may vary the pH at local site leads to Poor In vitro-In vivo correlation. Hence there is need to develop pH Independent drug delivery system to overcome all the limitations. There are few techniques such as Diffucaps technology, Use of pH modifiers, Use of surfactants, Combination of non ionic and Ionic polymers, Supersaturation technique along with nucleation inhibitors and Osmotic drug delivery to fulfil the object of pH Independent systems . These novel approaches may help the future research in gaining control over the significant drawbacks of pH dependent solubility of drugs.

Keywords: ionizable drugs, pH independent controlled drug delivery.

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