Abstract

DOES NESIRITIDE HAS THE POTENTIAL FOR TREATING HEPATIC SINUSOIDAL OBSTRUCTION SYNDROME IN CONJUNCTION WITH TIROFIBAN?

*Manoj G Tyagi and Bhavapriya R

Department of Pharmacology, Christian Medical College, Vellore 632002, Tamilnadu India.

ABSTRACT

The hepatic sinusoidal obstruction syndrome (SOS) also known as veno-occlusive disease (VOD) is characterized by jaundice, ascites and hepatomegaly. The incidence of SOS during hematopoietic cell transplantation varies depending upon the center and the definitions used for making a diagnosis. Rates as high as 50 percent have been reported, the current treatment for VOD is tissue plasminogen activator (t-PA) and cyclosporine. Apart from this defibrotide is an investigational treatment that may be promising. Defibrotide is a polydeoxyribonucleotide isolated from pig intestine.In this article we speculate the potential use of Nesiritide a 32 amino acid synthetic Brain natriuretic peptide analogue along with Tirofiban for treating the syndrome of VOD.

Keywords: Hepatic, Nesiritide, Tirofiban, Venules, jaundice.