Abstract

DESIGN & IN VITRO EVALUATION OF TOLFENAMIC ACID CONTROLLED RELEASE FORMULATIONS

Medikonda Gowthami, Ch. Saibabu, K. Thejomoorthy*

ABSTRACT

The present manuscript aims in preparing hydrophilic matrix of Eudragit RSPO and RLPO alone could not control the Tolfenamic Acid release effectively for 12 h. From the present study demonstrated that combination of both synthetic hydrophilic with hydrophobic polymers (Ethyl cellulose) could be successfully employed for formulating sustained-release matrix tablets. Diffusion coupled with erosion might be the mechanism for the drug release from hydrophilic and hydrophobic polymer based matrix tablets which can be expected to reduce the frequency of administration and decrease the dose-dependent side effects associated with repeated administration of conventional Tolfenamic Acid tablets. Hence, very promising invitroresults were observed with Controlled formulations of Tolfenamic Acid, further there is a scope to conduct the Preclinical and Clinical Studies to know the exact pharmacokinetics of the developed CR formulations of Tolfenamic Acid.

Keywords: The present manuscript aims in preparing hydrophilic matrix of Eudragit RSPO and RLPO alone could not control the Tolfenamic Acid release effectively for 12 h.