Abstract

FORMULATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF STAVUDINE

M. Hari Krishna, Ch. Saibabu, K. Thejomoorthy*

ABSTRACT

Mucoadhesive microspheres of Stavudine were conveniently prepared by orifice ionic gelation method using sodium alginate-mucoadhesive polymers (synthetic/natural) and mucilage isolated from the natural source. The production yields were in the range of 84.51±0.38 to 95.56±0.31 and the percentage drug content were in the range of 95.21±0.45 to 99.12±0.45 with low SD and CV value indicating uniform distribution of drug within the various batches of microspheres prepared with negligible loss during the formulation stage. It is mainly attributed to the influence of swelling property on the release of the drug from the microspheres. The mucoadhesive microspheres prepared with mucilage isolated from natural sources incombination with chitosan exhibit the release rate with respect to the type of mucilage. Microspheres prepared mucilage isolated from lady’s finger shows maximum drug release when compared to microspheres prepared mucilage isolated from fenugreek and Urad dal. The dissolution data were subjected for model fitting using dissolution software PCP DISSO V.3. The release from the mucoadhesive polymers follows higuchi matrix and peppas model. In all formulations the release exponent ‘n’ was found to be less than 0.5 indicating the release was fickian mechanism indicating the release rate was diffusion controlled.

Keywords: The release from the mucoadhesive polymers follows higuchi matrix and peppas model.