Abstract

FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING DOSAGE FORMS OF LAMIVUDINE

Katta Srinivasa Rao, Ch. Saibabu, K. Thejomoorthy*

ABSTRACT

Lamivudine multi unit granule GFDDS with controlled matrix cellulose and lipoidal polymers were prepared by different granulation techniques in the ratio of 1:1, 1:1.5 and 1:2. Lamivudine multi unit formulations comprising cellulose polymers were prepared by wet granulation technique, where as the Lamivudine multi unit formulations comprising lipoidal / fatty polymers were prepared by melt granulation technique. All the multi unit granule formulations (F1 to F21) prepared were evaluated for drug content and all the formulations had shown good results with in the official limits. They are even assessed for flow characteristics like bulk density, tapped density, Carr’s index and Hausner ratio. Formulations with cellulosepolymers had shown excellent flow charcters where as formulations prepared employing lipoidal polymers had shown a bit infereior results to cellulose polymers as they are prepared by melt granulation, but are passable .Assessment of dissolution study results revealed that formulations F7 (Lamivudine: Gelucire 43/01– 1:1), F10 (Lamivudine: Compritol 888 ATO – 1:1.5) and F19 (Lamivudine: Lubritab – 1:2) had retarded the drug release in controlled manner upto 12 hours. Hence these formulations were considered as promising formulations.

Keywords: They are even assessed for flow characteristics like bulk density, tapped density, Carr’s index and Hausner ratio.