Abstract

ANTIOXIDANT AND VITAMIN C IN THE SERA AND LEUKOCYTES OF NIDDM PATIENTS: A COMPARATIVE ANALYSIS

Ahmed Chyad Abbas*, Asawer Hassan Najm and Alaa Hussein Ali

ABSTRACT

The present study involved the examination of (100) patients (50 M and 50 F) suffering from Diabetes Mellitus type II (NIDDM), and (100) (50 M and 50 F) of healthy control from Patients were recruited from Alseder hospitals in Najaf between April 2024 and October 2024. The concentration of vitamin C was measured in the serum and Leukocytes in NIDDM patients. In addition the concentration of antioxidant such as glutathione, cholesterol, malondialdehyde uric acid and creatinine were measured. Compared with healthy control, vitamin C concentration was found significantly decreased in serum and leukocytes except in diabetic female patient, which decreased but not significantly. The concentration of glutathione was found significantly decreased compared with healthy control, while the concentraion of uric acid and creatinine were found significantly increased as compared with healthy control. The activity of creatinekinase was found significantly increase , as well as, the concentration of malondialdihyde and total cholesterol compared with that found in healthy control.

Keywords: Diabetes Mellitus type II, glutathione, malondialdehyde and creatine kinase.