Abstract

EVALUATION OF ETHANOLIC EXTRACT OF LEAVES OF CENTELLA ASIATICA AND FLOWERS OF CLITORIA TERNATEA AGAINST SCOPOLAMINE-INDUCED COGNITION AND MEMORY IMPAIRMENT IN SWISS ALBINO MICE

*Dr. P. Muralidharan, P. Madhu Maya Devi, M. Vignesh, S. Swetha, L. Gopi and K. Yuvaraj

ABSTRACT

Neurode generative diseases encompass a spectrum of debilitating conditions characterized by progressive neuronal degeneration, leading to motor, sensory, and cognitive impairments. Conditions such as Alzheimer's, Parkinson's, and Huntington's diseases present significant challenges to global healthcare systems, particularly amidst aging populations. This work delves into the etiology and pathology of neurodegenerative diseases, highlighting the roles of genetic factors, protein misfolding, oxidative stress, inflammation, and environmental triggers in disease progression. Focus is placed on Alzheimer's disease, exploring its clinical manifestations, pathophysiology, and the therapeutic potential of pharmacological agents, herbal remedies, and lifestyle interventions. Despite advances in understanding its molecular underpinnings, including beta-amyloid plaque formation and tau protein aggregation, effective treatments remain elusive. Emerging approaches such as flavonoids and alkaloids demonstrate promise in mitigating neuroinflammation and oxidative stress. This studyunderscores the critical need for interdisciplinary research and innovative therapeutic strategies to address the escalating burden of neurodegenerative diseases globally.

Keywords: ? Neurodegenerative diseases ? Alzheimer's disease ? Parkinson's disease ? Huntington's disease ? Amyloid plaques ? Tau protein aggregation ? Neuroinflammation ? Oxidative stress ? Protein misfolding ? Cognitive impairment ? Therapeutic strategies ? Herba