Abstract

NON-IONIC SURFACTANT BASED VESICLE 'NIOSOME' AS A POTENTIAL OCULAR DRUG DELIVERY SYSTEM

Raju. Manda*, Dr. R.Suthakaran, Virajaji Kaya, Bonagiri Sreedevi,
B. kusuma Pravallika.

ABSTRACT

The common principle for the success of pharmacotherapy is that the suitable drug should be present at the site of action in an effective concentration for a desired period of time. In ophthalmic treatment the site of action may be any ocular tissue, depending on where the disorder is located. Hence the drug should be targeted to many different sites within the eye. Poor bioavailability of drugs from ocular dosage form is mainly due to the tear production, non-productive absorption, transient residence time, and impermeability of corneal epithelium. Though the topical and localized application are still an acceptable and preferred way to achieve therapeutic level of drugs used to treat ocular disorders but the primitive ophthalmic solution, suspension, and ointment dosage form are no longer sufficient to combat various ocular diseases. The use of niosomes in combating the ophthalmic disorders is gaining momentum in the present scenario. This article reveals the importance in using niosomes as a potential ocular drug delivery system and highlights the need for the successful formulation, method of preparation and its characterization etc. to meet the future challenges and thereby rendering the dosage form for ocular therapy more effective.

Keywords: Ocular drug delivery system, Niosomes, Niosomes preparation, Non-ionic surfactant vesicle.