Abstract

REVOLUTIONIZING DRUG DELIVERY WITH IN SITU GELS: A NEW APPROACH TO CONTROLLED AND TARGETED THERAPY

*Madhura Yadav, Ankita Mohite, Sanjana Sankpal and Dr. Sadhana R Shahi

ABSTRACT

In situ gelling drug delivery systems are designed to release drugs slowly over time, maintaining steady drug levels in the body. These gels transition from a liquid to a gel when exposed to body fluids, temperature, pH, or specific chemicals. Compared to traditional systems like implants, in situ gels are easier to produce, cost-effective, and ideal for topical treatments. The gel’s phase transition is influenced by various stimuli, and mucoadhesive polymers like carbopol and chitosan help improve drug retention on mucosal surfaces, enhancing therapeutic outcomes. Recent research has explored their use for buccal, ocular, nasal, and vaginal drug delivery.

Keywords: ? In Situ Gel ? Controlled Release ? Polymer-Based Systems ? Mucoadhesion ? Drug Release Kinetics ? Gel Phase Transition