Abstract

TRANSUNGUAL DRUG DELIVERY SYSTEM NANOSYTEMS FOR THE TREATMENT OF ONYCHOMYCOSIS

*Prof. Dr. Kinjal Bipin Kumar Gandhi, Fidha Abdulrahman, Alfina Ashraf, Aishabeevi O. N., Fathima Suhaila K. A.

ABSTRACT

The potency of medications is reduced at the site of action when administered orally or systemically. Topical administration is used to prevent this loss of medication potency. To have a stronger therapeutic effect, the medications must be absorbed into the nail unit and nail plate. Oral toxicity of some medications, such as antifungals, can be prevented and pharmaceuticals have a longer contact duration at the application site. Topical therapy is extremely desirable for treating nail diseases because of its targeted effects, which lead to reduced side effects and maybe better adherence. The low drug permeability through the nail plate limits the efficacy of topical treatments. To improve medicine distribution through the nails, chemical permeation enhancers have been used frequently. Using various mechanical, physical, and chemical techniques to increase medication penetration through the nail plate was one possible way to get around the problem. Unfortunately, these procedures may be costly, need to be performed by a specialist, or could cause discomfort or more severe adverse effects. Additionally, topical formulations like patches and nail lacquers don't have enough long-lasting effects. Newer treatments foronychomycosis, like nanovesicles, nanoparticles, and Nano emulsions, have recently surfaced. These treatments are effective and may not have any negative side effects. With an emphasis on cutting-edge findings about formulation systems, this study outlines therapeutic tactics like mechanical, physical, and chemical procedures and highlights a variety of novel dosage forms and Nano systems created in the past ten years.

Keywords: Permeation, Nail lacquers, Transungual, Nano systems.