Abstract

OPTIMIZING IMMUNIZATION STRATEGIES FOR ENHANCED EFFICACY IN CAR T CELL THERAPY

*Ayyan Ataulla Kadiri, Sohail Saleem Gaziyani and Prof. Mangesh Tote

ABSTRACT

chimneric antigen receptor (CAR)T- Cells are an emerging important therapy in cancer. Post CAR T-cell synthesis cells are Analyzed for Identity, Purity, safety & Potency Immunization boost increases the Potency & safety of CART cell therapy through antigen mediated action at cancer directed target. Amph ligand therapy increases Donor cell Polyfunctionality & short Duration of Treatment but CAR-T cell plus radiotherapy increases anti tumor affects. Drawbacks or limitation are High costs, Adverse reaction and limited efficacy to solid tumors. The opportunities to still increase CART-T Cell efficacy, delivery efficiency and specificity offer hope for long term cure for many more patients with cancer. In this review we discuss the rationale and challenges of boosting, immunization, drawbacks and future prospects of CART T Cell therapy.[1]

Keywords: Drawbacks or limitation are High costs, Adverse reaction and limited efficacy to solid tumors.