Abstract

A REVIEW ON RECTAL SUPPOSITORIES: FORMULATION AND ABSORPTION

Satvi Mayur Mahesh**, Abhijit Rode and Akshay Jadhav

ABSTRACT

Suppositories are solid medications made by molding or pressing thatare inserted into body cavities like the rectum, vagina, or urethra.Research into the rectal membrane is valuable for both biochemi calstudies and for creating new ways to deliver drugs that don’t absorbwell, such as certain water soluble drugs and peptides. For childrenand older adults, using rectal suppositories can be a good alternative totaking drugs by mouth. This route can af fect drug bioavailability andmay allow for a gradual release of the drug. Rectal artesunatesuppositories are especially helpful in treating severe malaria inchildren under six years old in remote areas where malaria is common.Over the last two decades, research has focused on improving thebioavailability of drugs given through suppositories. However,traditional solid suppositories can be uncomfortable, often causing aforeign body sensation,pain, and discomfort. Suppositories play an important role in drug delivery, and creatingeffective formulations requires understanding factors like base selection, drug compatibility,and patient comfort. The review will also cover physiological and pharmaceuticalconsiderations in rectal drug delivery, including both conventional and innovative methods.

Keywords: Suppository, Semisolid medication, Bioadhe sive, mucosal lining, First pass effect, Rectal Absorption.