Abstract

FORMULATION AND EVALUATION OF VIGABATRIN CONTROLLED RELEASE MICROCAPSULES BY USING GUM KONDAGOGU AS A NATURAL EXCIPIENT

Nelakurthi Manju Bhargavi*, Charamcharla Bhanu Chandu, K. Koti Veera Nagaiah, Tumbeti Haritha, Narne Mounika and Brahmaiah Bonthagarala

ABSTRACT

An ideal drug delivery system (DDS) should be able to deliver an adequate amount of drug, preferably for an extended period of time for its optimum therapeutic activity. Most of the drugs are inherently not long lasting in the body and require multiple daily dosing to achieve the desired blood concentrate onto produce therapeutic activity. To overcome such a problem, controlled release (CR) and sustained release (SR) delivery systems are receiving considerable attention from the pharma industry world-wide. A Controlled Release Drug Delivery not only prolongs the duration of action, but also results in predictable and reproducible drug- release kinetics. Multiparticulate dosage forms are receiving an immense attention as alternative drug delivery system for oral drug delivery even though single unit dosage forms have been widely used for decades. The most commonly used pharmaceutical solid dosage forms today include granules, pellets, tablets and capsules, out of which tablets being the most popular dosage form, accounting for 70% of all ethical pharmaceutical preparations. In thepresent investigation Vigabatrin controlled release microcapsules were prepared by ionic gelation method. Gum Kondagogu was used as controlled release coating polymeric material for the preparation of microcapsules. Sodium alginate and calcium chloride are used as encapsulating and crosslinking agents.

Keywords: Vigabatrin Controlled Release Microcapsules, Kondagogu, Natural Polymer, Controlled Release Drug Delivery.