Abstract

MENTAL DISORDERS ARE COORELATED WITH GUT MICROBOTA

Supriti Saha*, Nandini Shaw, Arpita Naskar, Srija Mondal, Nipa Nondi

ABSTRACT

The growing body of research investigating the relationship between the gut microbiota and mental health has revealed compelling evidence for the gut-brain axis as a key factor in regulating brain function and behavior. Dysbiosis, or imbalances in the gut microbiome, has been implicated in the pathophysiology of several mental health disorders, including depression, anxiety, autism spectrum disorder (ASD), and schizophrenia. Recent studies have explored the potential of probiotics, prebiotics, and other microbiome-modulating therapies as novel treatment strategies for mental health conditions. Despite promising findings, the mechanisms underlying the gut-brain connection remain complex and not fully understood, and results across studies have been inconsistent. Key challenges include individual variability in microbiome composition, methodological differences, and the need forlarge-scale, long-term clinical trials to validate the therapeutic potential of microbiome interventions. This review examines the current evidence on the impact of gut microbiota on mental health, highlights the limitations of existing research, and proposes future directions for further investigation, particularly in understanding the mechanistic pathways and optimizing personalized microbiome-based treatments. The future of gut microbiota research holds the potential for innovative therapeutic approaches that could revolutionize the management of mental health disorders.

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