Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE FLOATING PELLETS OF DOXAZOSIN BY USING SYNTHETIC AND NATURAL POLYMERS

*Sidram Arawattu, Divya M. P., Dr. Jesindha Beyatricks, Chandhana V., Dr. Lokesh S.
V., Akhila Pujari

ABSTRACT

Drug Delivery System: It describes the technologies that carry drugsinto or throughout the body. The concept of sustained release formulations was designed toachieve a prolonged therapeutic effect by continuously releasingmedication over an extended period of time after administration of asingle dose and to eliminate the need for multiple dosage regimens,particularly for those drugs requiring reasonably constant bloodlevels over a long period of time. Pellets are one of the most popular multi-particulate dosage forms.Pelletization is an agglomeration process that converts fine powdersor granules of bulk drugs and excipients into small, free-flowing,spherical or semi-spherical units, referred to as pellets. Pellets range in size, typically, between 0.5 mm and 1.5 mm The sustained release drugdelivery is to ensure safety and to improve efficacy of the drug as well as patientscompliance. The dosage release properties of matrix devices may be dependent upon thesolubility of the drug in the polymer matrix. Controlled and sustained release of drug application within the pharmaceutical industryrequire consistent smooth surface with a narrow size distribution, to ensure uniform coatingand accurate free flow of granules for filling operations (like capsule filling ), and this canbe achieved by extrusion spheronization technique. Extrusion spheronization is a multiple process of wet mass extrusion followed byspheronization to produce uniform size spherical particles, called as spheroids, pellets,beads or matrix pellets depending upon the material as well as process used for extrusionspheronization ► Pellets have been used in pharmaceutical industry for more than four decades with beginning of controlled release technology that fully impact of inherent advantages of pellets over single dosage form has been realized. Now day’s pelletization technology represents an efficient pathway for manufacture of drug delivery system Sustained Release Floating Pellets.

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