Abstract

ANALYTICAL TECHNIQUES FOR ESTIMATION OF EPROSARTAN MESYLATE: AN OVERVIEW

Rewar S*, Bansal BK, Yadav MR1 Singh CJ, Sharma AK

ABSTRACT

The Aim of the present review to study analytical and detection techniques for Estimation of Eprosartan Mesylate. Eprosartan Mesylate is a potent, long-lasting, non peptide antagonist of the angiotensin II type-1 (AT1) receptor that is indicated for the treatment of essential hypertension. It selectively inhibits stimulation of the AT1 receptor by angiotensin II without affecting other receptor systems involved in cardiovascular regulation. There has been significant research on broad range of analytical and detection techniques that could be useful in its estimation in formulations and biological matrices. Practical requirements for high-sensitivity analysis create challenges for routine analysis. There are a number of methods used, but to our knowledge, high performance liquid chromatography with UV detection is more likely to be popular. In this review discusses methods such as Ultraviolet (UV) spectrophotometry, High Performance Liquid Chromatography (HPLC), High Pressure Thin Layer Chromatography (HPTLC), Liquid Chromatography- Mass spectrophotometry (LCMS) and Capillary Zone Electrophoresis (CE).

Keywords: Eprosartan Mesylate, Angiotensin, Estimation Methods, Bulk formulation.