Abstract

PREFORMULATION STUDIES OF CEFIXIME FOR DISPERSIBLE TABLETS DELIVERY SYSTEM DEVELOPMENT

Mahmoud Mahyoob Alburyhi*, Maged Alwan Noman and Abdu Faisal Alemad

ABSTRACT

Cefixime (CFX) is a third-generation cephalosporin antibiotic with activity as a Bacteroide which is able to damage the bacterial cell wall by the mechanism of action through inhibition of penicillin binding proteins, and damage the peptidoglycan synthesis pathway. The main objective of the present study was to the preformulation studies were performed to know the development of formulation and evaluation of Cefixime dispersible Tablets to improve the bioavailability of Cefixime. In API development process, a detailed characterization of the API and other formulation components is usually carried out during the preformulation stage. The drug-excipient compatibility studies were conducted to characterize the drug Cefixime present in dispersible Tablets Delivery System DT. Preformulation, formulation and evaluation of Cefixime to avoid problems associated with conventional delivery system and one of the most recent antibiotics. In the present study that the compatibility was assessed by, HPLC, FTIR spectroscopy, and melting point apparatus, precompression parameters and powder flow properties. Results showed that physical mixtures ofCefixime and various excipients were evaluated for preformulation studies parameters. It was concluded that the drug Cefixime was found to be compatible with various excipients which were selected for the formulation development of the Cefixime DT except showed that Cefixime was incompatible with tween 80 and sodium saccharin. Formulation scientist from his experience and knowledge have to significantly in the preformulation study stage and is an important factor in the ADDS (Advanced Drug Delivery Systems) product development process.

Keywords: Cefixime, Compatibility, Excipients, Development, Preformulation, Formulation.