Abstract

REVIEW: HYDROMELLOSE-BASED FLOATING TABLETS DEVELOPMENT AND ASSESSMENT USING DIRECT COMPRESSION TECHNIQUE FOR METFORMIN HCL

Mayuri S. Pawar*, Harsha S. Chandpure, Pranjal N. Jadhao, Akash S. Jumble and H. S. Sawarkar

ABSTRACT

This study explores the development and evaluation of Hydromel lose-based floating tablets of Metformin HCl using direct compression techniques. Floating drug delivery systems (FDDS) offer a promising approach to control drug release and improve therapeutic efficacy by retaining the drug in the stomach for extended periods, enhancing absorption, and minimizing fluctuations in plasma levels. Hydromellose (HPMC), a key polymer, enables buoyancy and controls the release of Metformin. The study focuses on sustained-release formulations designed to reduce dosing frequency and improve patient compliance. Key aspects of the formulation, including pre-compression parameters (Bulk index, angle of sixty, compressibility and index, angle of repose) and post-compression characteristics (Tablet hardness, friability, floating behavior, and drug release), areevaluated to optimize the tablet's efficacy. Additionally, stability studies are conducted to ensure the formulation's reliability under various storage conditions. The floating tablets demonstrated prolonged gastric retention and consistent drug release, making them an effective means for managing diabetes with Metformin.

Keywords: Metformin, HPMC, Flatting Tablet, Sustained Release.