Abstract

EVALUATION OF ANTI-UROLITHIATIC ACTIVITY OF METHANOLIC EXTRACT OF CLEOME VISCOSA LEAVES BY ETHYLENE GLYCOL AND AMMONIUM CHLORIDE INDUCED UROLITHIASIS IN MALE ALBINO WISTAR RATS

Bhaghawan R. K.*, Tamilselvan G. and Senthil Kumar K. L.

ABSTRACT

Urinary stone disease is a common disorder estimated to occur in approximately 12% of the population, with a recurrence rate of 70-81% in males, and 47-60% in females. Occurrence of urolithiasis requires formation of nidus, its reaction and growth in the urinary tract which cause obstruction of the ureter.[1] Urolithiasis is a complex process which is a consequence of an imbalance between promoters and inhibitors in the kidneys.[2] An imbalance between urinary stone inhibitors and promoters has been suggested to be the cause of stone formation.[3] Promoters facilitate stone formation[4], but inhibitors decrease the initiation of supersaturation, nucleation, crystal growth and rate of aggregation. Despite considerable improvements in medical therapy such as the utility of extracorporeal shock wave lithotripsy (ESWL), there is no satisfactory drug to treat renal calculi.[5]

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