Abstract

SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND BIOLOGICAL SCREENING OF SOME METAL (II) COMPLEXES DERIVED FROM 5-BROMO-3-((2-HYDROXYQUINOLIN-3- YL)METHYLENEAMINO)BENZOFURAN-2- CARBOXAMIDE SCHIFF BASE LIGAND

M. B Halli*, Naghma Shaishta, K. Mallikarjun and S. S Suryakant.

ABSTRACT

The present article deals with the synthesis of new tridentate O, N and O donor Schiff base ligand via condensation of 3-amino-5- bromobenzofuran-2-carboxamide with 2-hydroxyquinoline-3- carbaldehyde under suitable experimental conditions. The complexes were found to have the general composition ML2, where M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II) and L = Schiff base. The chelation of the complexes has been elucidated in the light of analytical, IR, mass, ESR spectral and magnetic data. The measured molar conductance values shows that, the complexes are non-electrolytic in nature. The Schiff base ligand and its metal complexes screened for their antimicrobial activity against Bacillus subtilis, Escherichia coli, Aspergillus niger and Aspergillus flavus to assess their inhibiting potential by minimum inhibitory concentration (MIC) method. In addition, the DNA cleavage activities of all the complexes were studied by agarose gel electrophoresis method.

Keywords: Benzofuran Schiff base, Metal complexes, Antimicrobial activity and DNA cleavage.