Abstract

TO STUDY THE ADR AND MANAGEMENT OF DUAL ANTIPLATELET THERAPY (ASPIRIN AND CLOPIDOGREL) IN POST PERCUTANE0US TRANSLUMINAL CORONARY ANGIOPLASTY (PTCA)

G. Sampoorna, B. Kiranmai*, B. Sucharitha, Bobba Rama and Ramu

ABSTRACT

Background: Dual Antiplatelet Therapy (DAPT) is the gold standards treatment for cardiovascular complications. The management of DAPT in terms of cardiovascular complications require continuous monitoring as it is associated with increased risk of bleeding. The clinical Pharmacist can contribute to overcome this complication by designing an individualized dosage regimen which effectively reduce the mortality with morbidity in the patients. Aim: The study emphasizes on management of DAPT therapy and associated ADRs in post- Percutaneous-Transluminal-Coronary-Angioplasty (PTCA). Methods: It is a descriptive study carried out in 110 patients from the month of December 2021 to June 2021. The data is collected from patients and is evaluated by comparing with standard guidelines like ACC/AHA and ESC. The information which is cross checked with the determinedresponse to the antiplatelets. Results: A total of 110 patients were involved in the research which accounted for 66 male patients followed by 44 female patients. The majority of the patients involved in the study were between 41- 50 (61.18%). The DAPT (Aspirin + Clopidogrel) therapy was prescribed in 67.28% of the subjects Although the remaining subjects were treated along single antiplatelet (SAPT) therapy (Aspirin – 16.36%, Clopidogrel-16.36%). It was observed when the study that the therapeutic efficacy associate with the DAPT therapy is comparatively higher than single drug regimen. The ADRs associated with DAPT therapy was found to be 10 whereas the single drug regimen accounted for 4. Conclusion: The study emphasized on effectiveness and ADRs associated with the DAPT therapy and single antiplatelet regimen. During the study, it was observed that the ADR occurred in the patient associate with the comorbidities and had a longer duration of exposure. The research has emphasizes the importance of monitoring APT regimen from time to time in order to reduce the incidence of ADR thereby increasing the quality of life of a patient.

Keywords: Antiplatelet medications, bleeding, percutaneous coronary intervention, major adverse cardiovascular events.