Abstract

ANTIBIOTIC COMBINATION THERAPY: A COMPREHENSIVE STRATEGY TO COMBAT DRUG RESISTANCE

Shubhangi B. Bhokre*, Sharvari S. Badukale, Manali M. Bode, Dr. Harigopal S. Sawarkar, Vaishanavi R. Ambulkar and Gajanan M. Jawalkar

ABSTRACT

A major worldwide health concern is antibiotic resistance, which is associated with higher rates of morbidity and mortality. Since more than 250 million antibiotics are prescribed each year, treating illnesses has become more challenging due to the rise of bacteria that are resistant to these drugs. The mechanisms of antibiotic resistance, including as genetic mutations and efflux systems, are covered in this study along with the use of combination antibiotic therapy (CT) as a calculated tactic to lessen resistance. To prevent toxicity and the selection of resistant organisms, Combination therapy must be used sparingly even if it can increase antibacterial efficiency against resistant strains. The study goes on to discuss how crucial it is to comprehend pharmacodynamics in order to create treatment plans that work and emphasizes the pressing need for a multipronged strategythat includes pharmacological, educational, and political measures to fight antibiotic resistance. In the end, optimizing results and reducing the development of resistance depend on modifying antibiotic treatment according to susceptibility profiles.

Keywords: Antimicrobial Resistance (AMR), Combination therapy, Bioflim formation, Antibiotic Combination.