Abstract

FORMULATION AND EVALUATIONS OF ORAL DISINTEGRATING TABLETS OF NIMODEPINE BY SIEVE METHOD

Kuluru Harika*, K. Ramalakshmi, K. Gopal, K. Vijayasantoshalaxmi, V. Urukundu, M J Sarah Ruth

ABSTRACT

1.1. ORAL DISINTEGRATING TABLETS (ODT)Oral administration is the most popular route about 50-60% of total dosage forms are administered due to ease of ingestion, pain avoidance, versatility (To accommodate various types of drug candidates), and most importantly patient compliance. Solid oral delivery systems do not require sterile conditions and are therefore less expensive to manufacture.[1] One important drawback of solid dosage forms is the difficulty in swallowing (Dysphasia) or chewing in some patients particularly pediatric and geriatric patients.[2] The problem ofswallowing is common phenomenon in geriatric patient due to fear of choking, hand tremors, dysphasia and in children‟s due to underdeveloped muscular and nervous systems and in schizophrenic patients resulting in poor compliance with oral tablet drug therapy which leads to reduced overall therapy effectiveness. Difficulties in swallowing of tablet and capsule also occur when water is not available, in diarrhea, coughing during the common cold, allergic condition and bronchial infection.

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