Abstract

MUCOADHESIVE DRUG DELIVERY: A REVIEW OF CURRENT INNOVATIONS

Senthil Prabhu R.*, Sathiyarasu S., Balaji S., Govindhan A. and Suresh M.

ABSTRACT

Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time of the dosage form at the site of absorption. The drugs which have local action or those which have maximum absorption in gastrointestinal tract (GIT) require increased duration of stay in GIT. Thus, mucoadhesive dosageforms are advantageous in increasing the drug plasma concentrations and also therapeutic activity. In this regard, this review covers the areas of mechanisms and theories of mucoadhesion, scope, factors influencing the mucoadhesive devices and also various mucoadhesive dosage forms.

Keywords: Mucoadhesion, Theories, Mucoadhesive dosage forms.