Abstract

EMERGING THERAPIES FOR PARKINSON’S DISEASES: A REVIEW OF NOVEL PHARMACOLOGICAL APPROACHES, CURRENT PRACTICES AND CLINICAL STUDIES

P. Subathiradevi*, S. Keerthana and V. Thiriburavaishnavi

ABSTRACT

The quality of life of patients with Parkinson's disease (PD), a complicated neurodegenerative illness marked by both motor and non-motor symptoms, is greatly impacted. Even with improvements in treatment choices, existing medications frequently simply alleviate symptoms, underscoring the need for creative solutions. An overview of new pharmacological treatments, existing procedures, and continuing clinical research in the treatment of Parkinson's disease is what this thorough study seeks to deliver. Promising new pharmacological treatments, such as gene therapies, immunotherapies, and small molecule inhibitors, have been discovered recently. These treatments focus on a number of pathogenic processes, including inflammation regulation, neuroprotection, and dopamine restoration.GLP-1 receptor agonists, A2A receptor antagonists, and LRRK2 inhibitors are noteworthy examples that have shown promise in preclinical and clinical research. This study also covers contemporary methods such as levodopa treatment, deep brain stimulation, and lifestyle changes. The potential for targeted therapeutics and combination treatments to enhance PD management is emphasized, along with ongoing clinical investigations and future research goals. The study also discusses the prospects and difficulties in PD research, emphasizing the value of cooperation between patients, physicians, and researchers. In order to help patients, researchers, and physicians better grasp the changing landscape of PD care, this review synthesizes existing information and new developments. This thorough review ultimately seeks to aid in the creation of successful treatments, enhancing the quality of life for those afflicted by Parkinson's disease.

Keywords: Parkinson’ disease, Pharmacological Approaches, Clinical Studies, Deep Brain Stimulation.