Abstract

REVIEW OF EXPERIMENTAL ANIMAL MODELS OF GLAUCOMA AND THEIR FUTURE PERSPECTIVES

Karthigadevi K.*, Leela Devi B., Purushothu S., Ramprasath V., Swetha D. and Anbazhagan S.

ABSTRACT

Glaucoma is a complex group of eye disorders characterized by progressive optic nerve damage, often associated with elevated intraocular pressure (IOP). It is a leading cause of irreversible blindness worldwide. Although research in the field of glaucoma is substantial, the pathophysiologic mechanisms causing the disease are not completely understood. A wide variety of animal models have been used to study glaucoma. In this paper we present a summary of most of the animal models that have been developed and used for the study of the different types of glaucoma, the strengths and limitations associated with each species use, and some potential criteria to develop a suitable model for future perspectives.

Keywords: Glaucoma, Optic nerve damage, Intraocular pressure, Animal models.