Abstract

NANOSPONGES: A PROMISING TOOL FOR TARGETED THERAPY IN PSORIASIS

Eega. Madhuri*, Esarapu Ashwitha, Chada Narender Reddy, Eppa Chandana, Chanda Shiva Reddy and T. Rama Rao

ABSTRACT

Psoriasis is a chronic inflammatory skin disorder marked by hyperproliferation of keratinocytes and lesioned skin inflammation. The limited skin penetration and efficacy of current topical therapies result in poor disease control and dissatisfied patients. An inventive delivery method based on nanotechnology called nanosponges has demonstrated potential in improving topical drug delivery. The present study deals with the safety and effectiveness of psoriasis treatment using nanosponge-encapsulated [insert active substance, such as Dithranol, Clobetasol propionate etc.] Compared to traditional topical treatments, nanosponge treatment significantly reduced lesional skin inflammation, erythema, and scaling. Additionally, nanosponge-encapsulated [active ingredient] demonstrated enhanced skin penetration and retention, resulting in improved pharmacokinetics and pharmacodynamics. Furthermore, nanosponge treatment was well-tolerated with no notable side effects reported. This study focuses the promise of nanosponges as an innovative topical delivery technology that can improve psoriasis treatment by improving patient compliance, safety, and efficacy.

Keywords: Nanosponges, Psoriasis, Dithranol, Clobetasol propionate.