Abstract

DEVELOPMENT OF NEW ANALYTICAL METHODS FOR THE ESTIMATION OF FLUPIRTINE MALEATE IN BULK AND IN FORMULATIONS

*M.Ramakrishna

ABSTRACT

A simple, sensitive, accurate and rapid caloremetric method were developed for the estimation of Flupritine in pure and capsule dosage forms. Flupritine react with MBTH to form a wine red coloured compound. Flupritine maleate contain free amino group that oxidised with Fecl3 solution and form a wine red coloured with the MBTH reagent and the coloured complex which can be estimated by colourimetrically. The colour of the solutions were measured the absorbance at 530.5 nm. Sandell’s sensitivity, molar extinction coefficient, slope, intercept, LOD and LOQ were determined. The percentage recovery was found to be 101.21 ± 0.25. The proposed method was accurate, precise, reproducible and economical for the routine analysis of Flupritine in bulk drug and in formulation.

Keywords: Flupritine, MBTH, distilled water UV? visible spectrophotometry.