Abstract

INSULIN REGULATION, INSULIN SECRETION AND ALTERNATION IN INSULIN SIGNALLING IN TYPE-2 DIABETES

Anchal Sharma*

ABSTRACT

The study investigates the impact of glucose and incretin hormones on insulin secretion and the involvement of the PI3K/Akt signaling pathway in pancreatic β-cells. By utilizing INS-1E β-cell lines and primary murine β-cells, the research demonstrates that glucose stimulation leads to a notable surge in insulin secretion, a response that is amplified by GLP-1. Inhibition of the PI3K pathway results in a decrease in both insulin secretion and signaling activity. These findings underscore the critical contribution of PI3K/Akt signaling in regulating insulin production, providing valuable insights for potential therapeutic approaches in managing type-2 diabetes.

Keywords: Insulin secretion, glucose, GLP-1, PI3K/Akt signaling, pancreatic ?-cells, type-2 diabetes.