Abstract

A RESEARCH ON FLURBIPROFEN LOADED ETHOSOMAL GEL: DESIGN, OPTIMIZATION, AND ANTI- INFLAMMATORY ACTIVITY

Monalee Rajabhoj*, Eknath K. Mahajan, Shamal G. Bhosle, Shubhangi D. Bunge, Hansraj B. Teple

ABSTRACT

The present study aimed for developing Flurbiprofen -loaded Ethosome by applying a quality by design (QbD) approach. Flurbiprofen loaded were fabricated, optimized, and evaluated. Flurbiprofen loaded formulations were prepared by cold method method using 32 factorial design. The independent variables soya lecithin concentration, cholesterol concentration, and ethanol concentration at 3 levels were used for optimization of the formulations. A structured experimental design matrix with thirteen experiments was built according to 32 factorial design to determine the impact of independent factors on dependent responses viz., particle size (Y1), Zeta potiential (PDI) (Y2), Entrapment efficiency EE (Y3). The response surface methodology (RSM) was used to optimizeEthosome formulation. The developed preliminary batches of Ethosome showed vesicle size of 110 to 348nm, zeta potential in between -55mV to -44Mv, % drug entrapment in range of 60.82 to 79.72% and drug content 16.13 to 57.21 %. The results of optimized Ethosomes showed particle size of 110 nm, zeta potential -46.64, entrapment efficiency of 65%and 7.4 mg drug content. The cumulative release from Ethosome was determined to be 33.27% at the end of 24 h. The results implied that Ethosome could effectively improve the solubility and bioavailability. Therefore, ethosomal gel formulation is a potential method to improve the solubility and bioavailability of Flurbiprofen, which has strong practicability.

Keywords: Flurbiprofen, Ethosomal Gel.