Abstract

TESTING THE ANTIDIABETIC ACTIVITY OF SUNGKAI LEAF EXTRACT (PERONEMA CANESCENS JACK) ON MALE WHITE MICE.

Mimi Aria*

ABSTRACT

Research has been carried out on testing the antidiabetic activity of sungkai leaf extract (Peronema canescens Jack) on male white mice induced by dexamethasone and glucose 10. This research uses an experimental method which uses 30 male white mice as experimental animals, divided into 6 groups and each -Each group consisted of 5 mice consisting of negative control, positive control, varying doses of 75 mg/kgBW, 150 mg/kgBW and 300 mg/kgBW and a comparison group of glibenclamide. The inducers used were dexamethasone 5 mg/ml and glucose 10%. Dexamethasone induction was carried out for 7 days and continued with 10% glucose until the 14th day, then the test preparation was given until the 21st day. The mice's blood was takenthrough the lateral tail vein using an Easy Touch glucometer. The parameters looked at were blood sugar levels which were measured using the POCT (Point of Care Test) method and analyzed using Two Way Anova statistical analysis and Duncan's advanced test. The results of the study showed that the treatment group with doses of 75 mg/kgBB, 150 mg/kgBB, 300 mg/kgBB could reduce blood sugar levels in mice and the best dose in reducing blood sugar levels in mice was a dose of 150 mg/KgBB with a percent reduction of 41.03%.

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