Abstract

FORMULATION AND DEVELOPMENT OF PH SENSITIVE NANOPARTICLES LOADED HYDROGEL OF ROSUVASTATIN

Vaishnavi R. Akade*, Mangesh S. Khillare and Shital V. Narale

ABSTRACT

Objective: Difference of pH that exists between the skin surface and blood circulation can be exploited for transdermal delivery by incorporating medication into a polymer that is sensitive to pH. The pH-sensitive polymer Eudragit S100 (ES100) has a dissolving characteristic above pH 7.4. Transdermal drug delivery systems (TDDS) have been rapidly developed as a promising alternative to the oral delivery systems to provide controlled drug delivery and avoid the first-pass metabolism of drugs. Lately, lipid nanoparticles and liposomes have been employed as nanocarrier systems to improve medication transdermal and cutaneous absorption. The purpose of this work is to create and assess a rosuvastatin-laden hydrogel loaded with polymeric nanoparticles (PNPs) for the treatment of hyperlipidemia. Methods: To create the nanoparticles, a straightforwardnanoprecipitation approach was used, and a response surface quadratic model was then used to provide an optimal formulation. The produced nanoparticles were examined and added to a hydrogel based on Carbopol 934. On the developed formulation, in vitro release and accelerated stability investigations were performed. Results: An encapsulation efficiency of 88% was achieved with particles with an average size of 45–88 nm. According to release studies, the hydrogel showed continuous release at pH 7.4 without any initial burst effect, while the nanoparticles remained stable at acidic pH. These nanocarriers' penetration into the hydrogel matrix. Results: Particles with an average size of 45–88 nm were obtained with an encapsulation efficiency of 88%. Release studies revealed that nanoparticles remained stable at acidic pH while sustained release with no initial burst effect was observed at pH 7.4 from the hydrogel. Permeation of these nanocarriers from hydrogel matrix. Conclusion: It can be concluded that Rosuvastatin PNPs-loaded Hydrogel was prepared effectively and shown encouraging permeability and release qualities.

Keywords: Hyperlipidemia, Atherosclerosis, low–density lipoprotein (LDL), Rosuvastatin, transdermal drug delivery system, Polymeric nanoparticles, Hydrogel.