Abstract

DEVELOPMENT AND EVALUATION OF CONTROLLED RELEASE FORMULATON OF TIZANIDINE HCL LOADED SOLID LIPID NANOPARTICLES

Dr. Samiksha P. Warke*, Rajashri V. Patil and Pallavi Joshi

ABSTRACT

Majority of newly developed drug entities and existed drugs has beenfacing the problem of poorly aqueous solubility. For poorlysoluble drug rate limiting step in drug absorption is drugdissolution. So ultimately poor aqueous solubility of drug leads topoor bioavailability related issues. Tizanidine HCl is anantispasmodic drug used for reduction of muscle pain Tizanidine HClis practically insoluble in water and its bioavailability is 40% due to itspoor aqueous solubility. Tizanidine HCl is poorly water-HClsoluble drug; its oral bioavailability can be improved by making solidlipid nanoparticles using Glyceryl monostearate. These polymers havebeen reported to improve the dissolution rate of poorly water -soluble drugs. The present work is an attempt to improve the solubility,and also make it controlled release of Tizanidine HCl formulation. The main objective ofpresent work is To enhance the solubility and improved the bioavailability of TizanidineHCl using lipid like glyceryl Monostearate. To prepare Tizanidine HCl loaded solid lipidnanoparticles and evaluate for solubility, drug polymer interaction, differential scanningcalorimetry, X-ray diffraction, dissolution study, scanning electron microscopy. To prepareformulation containing Tizanidine HCl loaded solid lipid nanoparticles and evaluated for itsdissolution studies and compared with marketed formulation.

Keywords: Solid lipid nanoparticles, Tizanidine, dissolution, X-ray diffraction, bioavailability.