Abstract

A REVIEW ON FORMULATION AND EVALUATION OF PIROXICAM LOADED SOLID LIPID NANOPARTICLES FOR TOPICAL DELIVERY

Dr. Praveen Kumar Ashok, Mrs. Archana Rautela, Ms. Soni and Sateesh Yadav*

ABSTRACT

Piroxicam is an anti-inflammatory, analgesic, and antipyretic drug.Piroxicam is widely used in themanagement of chronic pain. Theobjective of this work was to develop and analyze topical piroxicamLoaded Solid Lipid Nanoparticles to improve drug solubility, enhancepermeation, reduce GIT side effects reduce the frequency of the drug.The piroxicam Loaded Solid Lipid Nanoparticles was prepared bydrawing the pseudo ternary phase picture and water titration procedure.Formulation was prepared by using isopropyl myristate as an oil,Tween 80 as an surfactant, n-butanol as Co-surfactant and water. It wasconverted to gel by using 1% Carbopol 940 and few dropsofethanolamine. The prepared formulation was characterized forthermodynamic stability, pH, droplet size, viscosity, electricalconductivity, dye solubility drug content, and in-vitro release using a Franz diffusion cell. Thepiroxicam Loaded Solid Lipid Nanoparticles formulation was thermodynamically stable onvisual inspection after beingtreated with a freeze-thaw cycle and centrifugation. pH offormulation was 6.5. The mean droplet size for ME gelwas 100±0.472nm. The viscosity of theThe piroxicam Loaded Solid Lipid Nanoparticles was 90.4±0.01 cps which showedNewtonian flow. Electrical conductivity and dye solubility testing confirmed that theNanoparticles was O/W. The piroxicam Loaded Solid Lipid Nanoparticles showed89.89% drugcontent and the release rate of piroxicam was 98±8.63% after 48h. It followed theKorsmeyer Pappas model whichmeans it was a based system. The piroxicam Loaded SolidLipid Nanoparticles formulation obtained remarkably inflatedskin retention for piroxicamover the piroxicam gel. It might act as a promising vehicle for the topical delivery ofpoorwater-soluble drugs.

Keywords: Piroxicam, Topical, Permeation, Nanoparticles.