Abstract

IN SILICO ADME/TOX ANALYSIS OF SELECTIVE PHYTOCHEMICALS GALLIC ACID, ELLAGIC ACID & CHEBULINIC ACID

Hrutuja Wagh*, Samiksha Kondhare, Shravanee Bhosale and Dr. Meera Deshmukh

ABSTRACT

Cancer stands as a prominent global health challenge, projected toincrease substantially in incidence over the next two decades.Addressing this, the exploration of plant-derived compounds foranticancer properties presents a promising avenue. Herbal remediesoffer a viable alternative to conventional cancer treatments, with someplant-derived products already recognized as anticancer agents.Through a meticulous review of literature across various databases,this study undertakes a comparative analysis of the pharmacokineticproperties of select plant species and synthetic drugs using advancedcomputational tools like SCHODINGER 14 version, ADMET 2.0, andSWISS ADME software. The findings demonstrate that activephytochemicals from plants exhibit favorable absorption, distribution,metabolism, and excretion profiles akin to synthetic drugs. Moreover, these compounds haveshowcased efficacy against various cancer types including breast, stomach, oral, colon, lung,hepatic, cervical, and blood cancers in preclinical studies. Additionally, there are commercialconsiderations and promising prospects for the development of plant-derived substances withanticancer activity.

Keywords: Herbal, phytochemicals, ADMET study, anticancer drug, ellagic acid, gallic acid, chebulinic acid.