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Abstract

FORMULATION AND CHARACTERIZATION OF PROMETHAZINE FILMS USING BUCCAL ROUTE FOR DELIVERY

Udichi Kataria*, Chandra Prakash Jain

ABSTRACT

Buccal delivery route has been extensively explored in the last decade for improving the bioavailability of the drugs undergoing significant hepatic first pass metabolism. Promethazine hydrochloride (PHZ) being one of such drug with low bioavailability and extensive hepatic metabolism was used for the present study. Controlled release buccal films containing PHZ were designed using carbopol and sodium alginate as formulation variables (factors) for optimizing bioadhesion and permeability coefficient. Bioadhesive strength tended to vary quite linearly in increasing order of Carbopol. Permeation of PZH was calculated ex vivo using porcine buccal membrane. The patches were evaluated for weight variation, thickness, surface pH, moisture absorption, Invitro residence time, mechanical properties, in-vitro release, ex vivo permeation studies and drug content uniformity. The experimental findings were found to be satisfactory and can be used as base for further studies.

Keywords: Promethazine, Buccal films, Emesis, Bioadhesion


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