Abstract

SYNTHESIS, IR, EPR, UV-VISIBLE CHARACTERIZATION AND IN VITRO ANTIMICROBIAL ACTIVITY OF MACROCYCLIC SCHIFF’S BASE AND ITS METAL COMPLEXES OF Mn(II) AND Co(II)

Jugmendra Singh, *Pallavi Jain*, Mukesh Tyagi

ABSTRACT

Novel macrocyclic Schiff’s base ligand and its transition metal complexes of Mn(II), and Co(II) have been synthesized and characterized. Mn(II) and Co(II) metal complexes of chelating macrocyclic Schiff’s base ligand have been synthesized using acetates and chlorides of the metals. All metal complexes were characterized by elemental analyses, molar conductance, magnetic moment measurements and spectral (UV-Vis, IR, and ESR) studies. The macrocyclic ligand acted as tetradentate ligand and coordinate with metal ions through nitrogen and oxygen atoms. The low molar conductance values in DMF indicated that the metal complexes were non-electrolyte in nature. The magnetic moments and electronic spectral data suggested octahedral geometry for the Mn(II) and Co(II) complexes. The ligand and metal chelates were screened in-vitro for antibacterial and antifungal activity. Well diffusion method was used for antibacterial and antifungal activity

Keywords: Schiff’s base ligand, Mn(II), Co(II), complexes, spectral studies, octahedral, antibacterial, antifungal.