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Abstract

DEVELOPMENT AND EVALUATION OF FLOATING BIO- POLYMERIC ALGINATE BEADS OF DICLOFENAC SODIUM - OBTAINED FROM Lens culinaris

Vikas Bhatt*, Rajni Karakoti, Arun Kumar Singh

ABSTRACT

The objective of this study was to isolate, characterize the biopolymer obtained from lentil (lens -culinaris) belonging to the family fabaceae and their use in development of dosages form. The biomaterial was isolated from lentil by non solvent addition method and characterized their physicochemical and phytochemical properties. Diclofenac sodium is used as model drug for the development of biopolymeric -alginate bead. Five Batches (F1-F5) of biopolymeric-alginate bead of Diclofenac Sodium were prepared from sodium alginate solution using lentil (a novel biopolymer) by using ionic gelation method. The different concentration of sodium alginate, biopolymer and cross linking agent CaCl2 were used. Formulated beads were evaluated for its entrapment efficiency, drug loading efficiency, buoyancy, size & shape and invitro release. Drug entrapment efficiency was found better by using optimized concentration of CaCl2 and biopolymer. Results of the present study indicates that formation of completely aqueous enviouroment avoiding the use of organic solvents to minimize the curing time of beads leaded to enhanced drug entrapment efficiency and the biopolymer serves as a better alternative excipient for the development of dosages and their prospective results was found to be with in the limit of Pharmacopoeial standard.

Keywords: Diclofenac sodium, Biopolymer, Lentil , Ionic gelation method , Polymer- blend.


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