Abstract

INNOVATIVE FORMULATIONS AND DELIVERY SYSTEMS FOR ENHANCING CURCUMIN BIOAVAILABILITY: A REVIEW OF RECENT ADVANCES AND FUTURE DIRECTIONS

Anya Bisht, Durga Nagarjuna Boga*

ABSTRACT

Arthritis, obesity, cardiovascular disease, type II diabetes, pancreatitis, metabolic and neurological disorders, and some forms of cancer can all be made worse by inflammation. Since ancient times, people have used compounds derived from plants to treat a variety of illnesses, including inflammatory disorders, and to maintain regular physiological processes. Turmeric contains a yellow coloring component called curcumin (diferuloylmethane), which is used to treat and prevent a number of inflammatory illnesses. Curcumin affects a variety of molecular targets, as demonstrated by several research, and can be used in clinics for a variety of therapeutic purposes. There is strong evidence that curcumin can inhibit the long-term survival of cancer cells as well as cell invasion, angiogenesis, and proliferation. Through the downregulation of inflammatory cytokines, transcription factors, protein kinases, and enzymes that promote inflammation and the onset of chronic illnesses, curcumin mediates anti-inflammatory actions. Furthermore, curcumin triggers caspase cascades to cause apoptosis via receptor-mediated and mitochondrial mechanisms. Curcumin has been found to be a well-tolerated, safe, and nontoxic medication. Clinical trials that are now ongoing indicate curcumin's potential use in the treatment of a range of inflammatory conditions. Unfortunately, curcumin's low bioavailability and poor absorption limit its application in clinical settings. This paper describes curcumin's possible pharmacological and therapeutic role, opening doors for the advantageous role of plant isolated compounds in treatment of various inflammatory diseases and cancer.

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