Abstract

REVIEW ON: AN INSIGHT AND ADVANCES IN OPTHALMIC DRUG DELIVERY SYSTEM

P. B. Rajpure* S. K. Banerjee, M. V. Gadhave, S.D. Godase, P. K. Shelke.

ABSTRACT

Ophthalmic drug delivery has long been a challenging task for pharmaceutical scientists seeking to alleviate various ocular diseases affecting the anterior and posterior segments. In order to deliver therapeutic agents to target tissues, the unique anatomical barriers of the eye must be circumvented effectively, without causing any patient discomfort or alteration in protective physiological mechanisms. This challenge is currently being met with the development of novel noninvasive delivery methods as well as improvements over existing techniques. Nevertheless a need for additional research and continuous innovation is still warranted. Hence, the aim of this review article is to discuss several Various approaches that have been attempted to increase the bioavailability and the duration of therapeutic action of ocular drugs can be divided into two categories. The first is based on the use of the drug delivery systems, which provide the controlled and continuous delivery of ophthalmic drugs. The second involves, maximizing corneal drug absorption and minimizing precorneal drug loss.

Keywords: ophthalmic drug delivery system, Intravitreal Implants, Occular inserts, Artificial tear inserts.