Abstract

THE RATIONAL FOR ANTI-ARTHRITIS AND THE MECHANISM THAT GOVERN THE EFFECTIVENESS OF THERAPIES

S. B. Sontakke*, S. P. Borkar, S. D. Zambare, S. M. Shinde and P. U. More

ABSTRACT

The degenerative joint condition known as osteoarthritis (OA) is marked by pain, inflammation, and deterioration of the cartilage. The function of cytokines, chemokines, and enzymes is highlighted in this review, which describes the inflammatory and pain pathways in OA. It looks into how inflammation and pain perception interact, with a particular emphasis on nociceptors and sensitization. The diagnostic standards and imaging methods for determining the severity of OA are covered. Both pharmaceutical and non-pharmacological treatments, such as painkillers, medications that modulate disease, physical therapy, and lifestyle changes, are assessed for their effectiveness. Recent developments in innovative formulations like medicine delivery based on nanotechnology and regenerative therapies areexamined. It also discusses conventional and scientific evidence for the effectiveness of herbal treatments when used in the management of osteoarthritis. It highlights the requirement for additional study to confirm their efficacy and safety. Researchers, physicians, and anyone else interested in learning more about this crippling illness can use this extensive data, which offers insights into the pathophysiology, diagnosis, and therapy of OA.

Keywords: Osteoarthritis, Inflammation, Diagnosis, Therapy, Treatment, Herbal.