Abstract

LIQUISOLID TECHNOLOGY FOR ENHANCING THE DISSOLUTION PROFILE OF IRBESARTAN BY USING DIFFERENT NON VOLATILE SOLVENTS AND CARRIER MATERIALS

Beedha Saraswathi*, Meesa.Rajendar

ABSTRACT

Irbesartan is a angiotensin II receptor antagonist, used for the treatment of hypertension. It is insoluble in water and high penetration capacity. Presently, liquisolid compact technique is found to be used extensively as one of the successful tool to enhance the solubility and dissolution of various poorly soluble drugs. The principle focus of this study is to formulate liquisolid compacts of Irbesartan to enhance its dissolution rate. Here, liquisolid compacts are fabricated using different non-volatile solvents (PG and Polysorbate-80) and converting them into acceptably flowing and compressible powders by using different carrier and coating materials (MCC, Starch 1500®, Anhydrous lactose, colloidal silicon dioxide) for efficient compact tablet production. The prepared blends are subjected to the pre-formulation studies or micrometric properties such as angle of repose, bulk density, tapped density, hausers ratio and carrs index and the compressed liquisolid compacts are evaluated for the physical parameters such as uniformity of weight, hardness, thickness, friability, disintegration, content uniformity and in-vitro dissolution. The SEM, FTIR, X-RD and DSC analysis are performed to confirm the compatibility of the drug with the excipients.

Keywords: Irbesartan, Dissolution enhancement, Poorly soluble drugs, Mathematical model, Solubility, Liquisolid compacts.