Abstract

ANTI OXIDANT PROPERTY OF PVFC – EXTRACTS IN A ROLE OF WEIGHT LOSS AGAINST HIGH FAT DIET INDUCED OBESITY IN RATS

P. Iswarya*, P. Saranya, L. Gopi, V. Kalvimoorthi, K. Kaveri and S. Swetha

ABSTRACT

Cholesterol is one of the vital, basic building materials of the body, but high levels of cholesterol can lead to CVD and, in some cases, to death. Present study includes recent research that has been done on cholesterol’s health benefits and risks, the absorption pathway of cholesterol, cholesterol lowering drugs, and plant sterols, the natural alternative to cholesterol reducing drugs. Plant sterols (also called phytosterols) are sterols synthesized only in plants and which mammals must obtain via their diets. The inclusion of plant sterols in so-called “functional foods” that aid in reducing one’s cholesterol level is a well-developed industry. Nonetheless, work continues on understanding the mechanism by which phytosterols lower serum cholesterol levels. In conclusion, the findings of the study suggest that MEMP showed a potent anti oxidant effect by lowering totalcholesterol, triglycerides, LDL, VLDL, Apo B, Apo B/AI ratio and by increasing HDL, Apo AI, and HDL/LDL ratio levels in the high fat diet fed rats. The mechanism has point towards inhibiting cholesterol and triglyceride synthesis. The drug also demonstrated for antioxidant properties in invivo antioxidant models. Probable mechanism may be due to the reduced cholesterol absorption, deranged endogenous lipid synthesis, and enhanced fecal cholesterol excretion. MEMP also showed in vivo antioxidant properties by facilitating the increased formation of free radical scavenging enzymes like SOD and catalase and reduced the extant of lipid peroxidation. It can be concluded that all the effects contributes for reducing the CVD due to atherosclerosis. Invitro target validation and the innate mechanisms responsible for antihyperlipidemic and anti oxidant mechanisms must be studied in detail further.

Keywords: Cholesterol, Obesity, Anti-Oxidant, Anti-Hyperlipidemic.