Abstract

DESIGN AND EVALUATION OF FLOATING SUSTAINED RELEASE TABLETS OF VALSARTAN HCl.

Deepika HC *, S.Srilatha

ABSTRACT

Valsartan, a widely prescribed anti-hypertensive drug which is an angiotensin II type 1 receptor antagonist belongs to BCS class IΙ .It shows absorption window in stomach area. The objective of the study is to develop a sustained release floating tablets of Valsartan to increase the Bioavailability of Valsartan. The present study was aimed to develop antihypertensive floating sustained release tablets of valsartan Angiotensin II receptor antagonist, using synthetic polymers like HPMC K 100 m, K4 m, E15cps, carbomer 940 P, and natural gums like guar gum, Xanthan gum for sustained drug release. The matrix tablets were prepared by direct compression method. All the excipients are tested for compatibility with drug, which revealed that there was no physical and chemical interaction occurred. The Pre formulation parameters such as bulk density, tapped density, compressibility index and Hausner’s ratio were analyzed. The In-Vitro drug release studied were Performed in the USP dissolution apparatus ((Type-2) using pH 1.2 HCL as dissolution media at 100rpm speed and temperature of 37oC ± 5oC. The sampling was done at periodic time intervals of 1,2,3,4,5,6,7,8,9,10,11 and 12 hours and was replaced by equal volume of dissolution media after each withdrawal. The cumulative amount of drug release at different intervals is estimated using UV method. Based on the evaluation result the formulations F6 (guar gum and carbomer 50:50) was selected as best formulation among sustained release and shown maximum release of 100.10% drug in 12th hour. Based on mathematical models the formulation F6 fitted into zero order and korsmeyer-peppas plot with 0.974 and 0.993 regression values respectively.

Keywords: Valsartan, guar gum, HPMC K100m, Carbomer, dissolution studies, sustained release.