Abstract

INCLUSION COMPLEXATION STUDY OF CURCUMIN AND H?-CYCLODEXTRIN

S. Bakkialakshmi*, G.Jayaranjani,

ABSTRACT

Curcumin is a lipid soluble polyphenolic antioxidant obtained from curcuma longa.However, the most intriguing aspect of this compound is that it shows a wide array of pharmaceutical activity, including potent antioxidant, anti-inflammatory, and anti-carcinogenic properties.One of the disadvantages of curcumin limiting its physiological activities is its insolubility in aqueous Solution, through it is possible to increase its solubility in water by forming inclusion complexes with water soluble host. There are several studies on host - guest complex formation of curcumin.Formation of such host – guest systems can be proved by observing absorption and fluorescence changes in curcumin. The photo - physical properties of curcuminvary(leave space) significantly depending on the medium and therefore act as suitable tools for following the inclusion behaviour to different systems. Cyclodextrin are one of the most widely used synthetic model host cavities, which provide a conical cavity for the water insoluble guests to be encapsulated, thereby making the water soluble.Here, an attempt has been made to estimate the formation constant of 1:1 curcumin and hydroxypropyl β-cyclodextrin (Hβ- CD) complex by following the absorption and fluorescence properties. The formation constant of the complex was determined by following absorption, fluorescence spectral changes.

Keywords: Curcumin, Hydroxypropyl ?-Cyclodextrin, UV absorption,Inclusion complex.