Abstract

SYNTHESIS, BIOLOGICAL EVALUATION OF SOME HETEROCYCLIC DERIVATIVES AS AN ANTIMICROBIAL AGENT

Sayali Dalvi* and Snehal Patil

ABSTRACT

Some new heterocyclic compounds containing benzimidazole and chalcone derivatives were prepared from various chalcones. The synthesized compounds have been characterized by TLC, IR, and 1H NMR spectroscopy methods. These compounds were screened for their antimicrobial activities. 2-aminomethyl benzimidazole fused with chalcone derivatives were synthesized by nucleophilic substitution reaction between 2-(chloromethyl)-1H-benzimidazole and N-3-((1H-benzo[d]imidazole-2-yl) methylamino)-3-phenylprop-1-enyl) phenol. First 2-(aminomethyl)-1H-benzimidazole was yielded by Phillip’s condensation of o-phenylenediamine with chloroacetic acid. Then these two moieties were fused by using nucleophilic substitution reaction to afford corresponding target compounds. The antibacterial activity of benzimidazole derivatives have been assessed with zone of inhibition by cup-plate method using a gram positive and gram-negative bacterial strain and which have showed good activity. The structures of the synthesized compounds were evaluated by spectral and elemental methods of analyses. All the synthesized compounds were screened for their antimicrobial activities. All of the derivatives showed good activity towards Gram-positive bacteria and Gram-negative bacteria.

Keywords: Benzimidazole, Chalcone derivatives, Antimicrobial activity.