Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS JUNE ISSUE PUBLISHED
  • JUNE 2020 Issue has been successfully launched on 1 June 2020.

Abstract

IN VIVO ANTIOXIDANT AND ANTIHYPERGLYCAEMIC PROPERTIES OF AQUEOUS EXTRACT OF A HERBAL COCKTAIL

1Ogugua V N, 2Egba S I٭, and 1Adoga J E.

1Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.
2Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria.

ABSTRACT

The antioxidant and antihyperglycaemic effect of herbal cocktail namely: vernonia amygdalina, Gongronema latifolium, Allium sativium, Ocimum gratissmun and Aloe barbadensis was studied on alloxan induced Diabetic Rat. Twenty (20) albino wistar Rats were equally divided into five groups. Groups 1 and 2 served as normal and untreated Diabetic controls. Test groups 3, 4 and 5 were treated with 10mg/kg glibenclamide, 200mg and 400mg/kg of extract for 28 days. The result showed a dose dependant significant increase (P<0.05) in serum concentrations of vitamin C, glutathione and catalase activity in test groups when compared to untreated diabetic control. Similarly, the extract significantly reduced (P<0.05) glucose concentration of diabetic rats at both concentrations when compared to untreated diabetic Rats. The results confirmed the already established use of these plants in traditional medicine and equally established their useful synergistic effect in reducing blood sugar and in relieving oxidant stress.

Keywords: Antioxidant, catalase, glutathione, alloxan, antihyperglycaemia, glibenclamide.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More