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Abstract

FORMULATION AND EVALUATION OF BI LAYER TABLETS OF IBUPROFEN AND FAMOTIDINE

Ranjit Goud.P*, Neeharika. M.S, Deepika HC, Sikanth CH, Tarika A, Manasa P

ABSTRACT

The main objective of this research work was to formulate and evaluate the bi layered tablets of ibuprofen and famotidine by using different polymers. Ibuprofen is an NSAID and famotidine is a H2 receptor antagonist. The tablets containing immediate releasing layer and sustained release layer. The ingredients used are microcrystalline cellulose pH 102, sodium starch glycol ate, cross carmellose, povidone for immediate releasing layer, HPMC K15m, K4m, E15cps, Carbomer 934p, and natural gums like guar gum, Xanthan gum for sustained drug release layer. The bilayered tablets were prepared by direct compression and wet granulation methods. All the excipients are tested for compatibility with drug, which revealed that there was no physical
and chemical interaction occurred. The Pre and post compression parameters were analyzed. The In-Vitro drug release studied were Performed in the USP dissolution apparatus-II (paddle) using pH 1.2 buffer and pH 6.8 phosphate buffer as dissolution media at 100rpm speed and temperature of 37oC ± 5oC. The sampling was done at periodic time intervals of 1.5, 3, 4, 6, 8, 10 and 12 hours and was replaced by equal volume of dissolution media after each withdrawal. The cumulative amount of drug release at different intervals is estimated using UV method at 219nm and 285nm. Based on the evaluation result the formulations F8 was selected as best formulation among immediate release and is used to compress with sustained release layer. Among all formulation F11 formulation was achieved 12hrs with HPMC k15m, kinetic model fitted to zero order release profile.

Keywords: Ibuprofen and famotidine, sodium starch glycolate, HPMC K15m, bilayered tablets formulation, immediate and sustained release, dissolution studies.


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