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Abstract

ANTI-INFLAMMATORY ACTIVITIES OF SIEBOLDOGENIN FROM OCIMUM SANCTUM: EXPERIMENTAL AND COMPUTATIONAL STUDIES

Priyadarshini Mallick*

ABSTRACT

(TCM) as well as in Pakistan for several medicinal purposes including their use in inflammatory disorders. The aims of the current study were to validate and assess the folk use of Ocimum sanctum on pharmacological grounds using the isolated compound at molecular, in vivo and computation at levels. Seiboldogenin was isolated from ethyl acetate fraction of the plant crude extract. In vitro lipoxygenase and in vivo carrageenan-induced hind paw edema models were used in experimental studies while molecular docking technique was used to conduct computational study. Sieboldogenin showed significant lipoxygenase inhibition (IC50: 38mM). It also exhibited significant inhibition (p < 0.05) of carrageenan-induced hind paw edema at the doses of 10 and 50 mg/kg. Computational molecular docking showed its molecular interaction with important amino acid residues in the catalytic site of lipoxygenase, revealing its potential binding mode at molecular level. Sieboldogenin seems to be a potential new anti-inflammatory compound responsible for anti-inflammatory activities of Ocimum sanctum It is in vitro and in vivo inflammatory activities are in good agreement with the folk medicinal use of Ocimum sanctum in inflammatory disorders.

Keywords: lipoxygenase, Ocimum sanctum, Seiboldogenin.


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